• Evaxion developed a genetic adjuvant expertise that enhances the immune responses of viral, bacterial and most cancers vaccines
  • Preclinically validated for each DNA and mRNA vaccines, and prepared for scientific testing  
  • Anticipated giant market potential for DNA and mRNA vaccines in opposition to most cancers, viral and bacterial illnesses

COPENHAGEN, Denmark, Might 25, 2023 (GLOBE NEWSWIRE) — Evaxion Biotech A/S (NASDAQ: EVAX) (“Evaxion” or the “Firm”), a clinical-stage biotechnology firm specializing within the discovery and improvement of AI-powered immunotherapies, at the moment unveils the expertise behind its novel, proprietary genetic adjuvant developed to boost the effectiveness of DNA and mRNA vaccines for infectious illnesses and most cancers. 

Newest information from the adjuvant program had been offered at Evaxion’s stay stream R&D Day, Might 25, 2023. 

“We’re excited to current this novel genetic adjuvant expertise to the worldwide scientific group. It boosts Evaxion´s personal DNA expertise and has the potential to enhance the impact of nearly any vaccine. We foresee an incredible market potential in that this expertise seems to be extremely efficient in each DNA and mRNA based mostly vaccines in opposition to most cancers in addition to infectious illnesses,” stated Per Norlén, CEO at Evaxion

Evaxion´s novel genetic adjuvant carries the code for CCL19, a molecule identified to draw immune cells, notably antigen presenting cells, and could be encoded into both DNA or mRNA vaccines with the goal of boosting the immune response. 

Newest information present that the genetic adjuvant expertise boosts the antitumor impact in preclinical tumor fashions, and induces neutralizing antibodies and T-cell responses in opposition to each viral and bacterial antigens: 

  • Supply of DNA or mRNA most cancers neoantigen vaccines induced robust neoantigen-specific T-cell responses and full antitumor responses
  • Supply of a COVID-19 T-cell epitope DNA vaccine resulted in a powerful and particular T-cell response and guarded in opposition to a deadly dose of the virus (90% survival)
  • Supply of a Neisseria Gonorrhoeae antigen DNA vaccine induced excessive antibody titers and particular T-cell responses in the direction of the bacterial antigens
  • Per Norlén continues, “By encoding the immune-stimulating molecule CCL19 into both DNA or mRNA vaccines, we now have demonstrated important enhancement of the vaccines effectiveness. We imagine that this development holds immense potential for vaccine improvement, because it boosts each B cell and T cell immune responses, making it relevant to a variety of vaccines. Constructing on the encouraging preclinical outcomes, the subsequent step is to validate the expertise in sufferers.” 

    Evaxion goals to carry the genetic adjuvant expertise into scientific trials later this yr as a part of the personalised most cancers immunotherapy program EVX-03.  

    Please go to the Buyers part of Evaxion’s web site to entry a replay of the R&D Day displays. 

    About Evaxion

    Evaxion Biotech A/S is a pioneering firm growing AI-powered immunotherapies. Evaxion’s proprietary and scalable AI applied sciences decode the human immune system to find and develop novel immunotherapies for most cancers, bacterial illnesses, and viral infections. Evaxion has a broad pipeline of candidates, together with three personalised most cancers immunotherapies. It’s positioned in Hørsholm, Denmark, with 50 workers listed on the Nasdaq New York inventory trade. For extra info, please go to www.evaxion-biotech.com.

    Ahead-looking assertion 
    This announcement accommodates forward-looking statements throughout the that means of Part 27A of the Securities Act of 1933, as amended, and Part 21E of the Securities Trade Act of 1934, as amended. The phrases “goal,” “imagine,” “count on,” “hope,” “goal,” “intend,” “might,” “would possibly,” “anticipate,” “ponder,” “proceed,” “estimate,” “plan,” “potential,” “predict,” “undertaking,” “will,” “can have,” “seemingly,” “ought to,” “would,” “may,” and different phrases and phrases of comparable that means determine forward-looking statements. Precise outcomes might differ materially from these indicated by such forward-looking statements because of numerous components, together with, however not restricted to, dangers associated to: our monetary situation and want for added capital; our improvement work; price and success of our product improvement actions and preclinical and scientific trials; commercializing any accepted pharmaceutical product developed utilizing our AI platform expertise, together with the speed and diploma of market acceptance of our product candidates; our dependence on third events together with for conduct of scientific testing and product manufacture; our incapability to enter into partnerships; authorities regulation; safety of our mental property rights; worker issues and managing development; our ADSs and strange shares, the impression of worldwide financial, political, authorized, compliance, social and enterprise components, together with inflation, and the results on our enterprise from the worldwide COVID-19 pandemic and the continuing battle within the area surrounding Ukraine and Russia; and different uncertainties affecting our enterprise operations and monetary situation. For an extra dialogue of those dangers, please seek advice from the danger components included in our most up-to-date Annual Report on Kind 20-F and different filings with the U.S. Securities and Trade Fee (SEC), which can be found at www.sec.gov. We don’t assume any obligation to replace any forward-looking statements besides as required by regulation.

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