The six month observational study of 91 adults with moderate joint well being concerns, performed by scientists at the iminosugar analysis firm PhytoQuest Restricted, concludes that just 20 mgs each day of the supplement considerably enhanced a variety of joint well being scores.

The analysis, published in Present Rheumatology Testimonials, ​also states that the final results have been dose dependent, so a larger Q-Actin concentration of one hundred mg decreased the OA-associated parameters by a higher extent.

The authors for that reason suggests there could be a personalised supplementation strategy needed with a particular dosage for an optimum activity for a provided age.

Discussing the mechanism of action, the authors hypothesise it is due to the anti-inflammatory activity of idoBR1 – the iminosugar amino acid isolated from cucumber.

Q-actin and iminosugars

Q-actin, marketed by the iminosugars developer IminoTech Inc, is a cucumber (Cucumis sativus L​.) extract containing the iminosugar ido-BR1 standardized to &gt 1%. 

Iminosugars are analogues of sugars in which the oxygen​ is replaced by a nitrogen​ atom. This substitution prevents regular metabolism resulting in inhibition of glycosidases​ and glycosyltransferases​.

These compounds are attracting interest as therapeutic agents due to their capability to interact with human glycosidases, other proteins, and sugar receptors. 

InimoTech says Q-actin functions by inhibiting Tumor Necrosis Element alpha (TNF-α), a chemical messenger immune cells release to assist orchestrate immune method responses to prospective threats or broken tissues.

A previously published randomised, double-blinded clinical study​ involving 122 adults reported that 20 mgs of Q-actin each day considerably enhanced joint well being in comparison with two,700 mgs of glucosamine-chondroitin more than a six-month period. Subjects have been evaluated at 30-day intervals utilizing WOMAC, VAS and LFI. Q-actin decreased WOMAC scores by 70% more than six months.

Earlier studies​ showed Q-actin/ido-BR1 decreased LPS-induced pro-inflammatory cytokine tumour necrosis aspect alpha (TNFα) in both ex vivo​ human serum and THP-1 cells. TNFα can drive degenerative adjustments such as in joints when chronically elevated.  Analysis shows that idoBR1 functions in a dose-dependent manner to cut down inflammatory markers, including LPS-induced production of TNFα, IL-six, nitric oxide and the transcription aspect NF-κ​B.

Study Style and Final results​

The current study enrolled 101 subjects with moderate osteoarthritis, 91 of which have been evaluable. Subjects have been divided into 3 groups taking a placebo or 20 mgs or one hundred mgs of Q-actin each day for six months. Following a baseline evaluation, subjects have been evaluated at 30-day intervals utilizing the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Visual Analogue Scale (VAS) and Lequesne’s Functional Index (LFI).

Each Q-actin groups knowledgeable important reductions in discomfort and improvements in other joint function parameters at just about every point of the study by just about every evaluation approach.  For instance, subjects taking 20 mgs each day of Q-actin knowledgeable a 32% improvement in WOMAC scores more than six months, compared with a five% improvement for the placebo group. The Q-actin well being advantages have been dose dependent. The WOMAC score of the one hundred milligram-group elevated 39% more than the duration of the study.

Shil Kothari, IminoTech Chief Executive Officer states: “It is outstanding that a each day serving of only 20 mgs of Q-actin developed important improvements in joint function, like the capability to full each day activities such as utilizing stairs, buying and operating at household.

“Q-actin’s each day serving size is a tiny fraction of top joint well being dietary supplement components. It opens the door to lots of new joint well being solution formats and applications.”

Supply: Present Rheumatology Testimonials​​

DOI: 10.2174/1573397119666230206105703

Standardised ido-BR1 Cucumber Extract Enhanced Parameters Linked to Moderate Osteoarthritis in a Placebo-controlled Study​.

Nash. R. J., et al