Nima Sharifi, M.D.

By Lisette Hilton

Nima Sharifi, M.D., has been named scientific director of the University of Miami Miller College of Medicine’s Desai Sethi Urology Institute, a function in which he will collaborate with Sylvester Extensive Cancer Center to drive translational science focused on prostate and other genitourinary cancers.

Presently the director of analysis on genitourinary cancers and endowed chair for prostate cancer analysis at Cleveland Clinic, Dr. Sharifi will bring members of his analysis group with him to Miami and recruit other people to develop a translational science group of investigators focused on bridging laboratory analysis on prostate, kidney and bladder cancers to human research.

“The Desai Sethi Urology Institute is expanding beyond supplying outstanding clinical care, with an huge commitment to science—not just fundamental or laboratory science, but also translational science to connect our understanding of quite fundamental mechanisms of illness associated to urology. A lot of that discovery is associated to prostate, kidney and bladder cancers and moving these findings into the clinic to transform care for individuals,” Dr. Sharifi mentioned. “My activity is to develop that translational foundation, which is comparable to what our group has accomplished at the Cleveland Clinic.”

Dr Sharifi was an aspirational option for the function of scientific director of  the Desai Sethi Urology Institute and will deliver transformational leadership inside each the Institute and Sylvester, mentioned Dipen J. Parekh, M.D., founding director of the Desai Sethi Urology Institute.

“Dr. Sharifi belongs to the highest echelon of doctor scientists who have led seminal discoveries in the fields of prostate cancer, steroid metabolism and human physiology. These findings have implications on cancers inside a number of organs and fills an unmet want in discovering novel targets for new drugs and molecules,” Dr. Parekh mentioned. “Findings from Dr. Sharifi’s labs are currently becoming tested in human clinical trials – a testimony to his excellence and applicability of his higher caliber science to make an actual clinical distinction.”

Genitourinary cancers are amongst the most frequently diagnosed cancers in the U.S., with prostate becoming the most widespread cancer amongst males.

“Our recruitment of Dr. Sharifi, collaboratively with the Desai Sethi Urology Institute sends a potent message that, as the only National Cancer Institute-designated cancer center in South Florida, Sylvester is committed to not only treating genitourinary cancers but also conducting the highest-level analysis, enhancing outcomes for individuals and discovering cures,” Sylvester Director Stephen D. Nimer, M.D. mentioned. “Since our NCI designation, we have continued to attract globe-top researchers like Dr Sharifi. Even though his location of concentrate is in prostate cancer, his knowledge and leadership will have an effect beyond GU cancers.”

Dr. Sharifi mentioned he and colleagues have demonstrated certain knowledge in metabolism and physiology as it relates to cancer.

“We totally intend to take this in a number of distinctive directions. For instance, at present we are searching at the interaction involving dietary intake and how that impacts metabolism in the context of males who have prostate cancer,” Dr. Sharifi mentioned. “That relates to nutritional intake, genetics and metabolism, and all of it comes with each other to influence either the danger for establishing cancer or how males with elements of metabolism have distinctive responses to hormonal therapy.”

This analysis is extremely relevant simply because a lot of of today’s prostate cancer treatments–hormone therapies, in particular–have side effects that are associated to metabolism.

“All of it definitely comes to the identical fundamental concerns of what definitely drives the illness and how can we use that details to boost outcomes for men and women who have these types of cancers, to remedy them or stop them,” Dr. Sharifi mentioned. “The ultimate target right here at the Institute and Sylvester, is to do quite thrilling higher-effect science, and to have that at some point connect back to the individuals. The clinical effect is definitely vital to me. Combining thrilling science with clinical impact–that’s the central concentrate of what we do. Our group is energized and excited for the operate we strategy to do with each other at the Desai Sethi Urology Institute and Sylvester.”



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